Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR.
Autosomal dominant polycystic kidney disease (ADPKD) is a commonly inherited renal disorder caused by defects in the PKD1 or PKD2 genes.ADPKD is associated with significant morbidity, and is a major underlying cause of end-stage renal failure (ESRF).Commonly, treatment options are limited to the management of hypertension, cardiovascular risk facto